Statistical Insights

Counting the Costs of Clinical Trials: Why Rethinking Trial Design Matters

Counting the Costs of Clinical Trials: Why Rethinking Trial Design Matters 260 200 Exploristics

By Exploristics CEO – Aiden Flynn 

Clinical development is extremely costly, in terms of money, time and patient burden. Financially, the median cost of a clinical trial supporting FDA approval of a new drug is US$19M [1], while the …

Estimands – The “what” and the “how” of drug discovery

Estimands – The “what” and the “how” of drug discovery 260 200 Exploristics

By Exploristics Chief Data Scientific Officer – Kimberley Hacquoil

In clinical development, clear, precise and transparent specification of the research question and associated treatment effects of interest are vital. This is especially crucial as trials often involve multiple stakeholders who …

Embedding New Technologies into Clinical Studies

Embedding New Technologies into Clinical Studies 260 200 Exploristics

Embedding New Technologies into Clinical Studies

By Exploristics Chief Data Scientific Officer – Kimberley Hacquoil

Recently, I attended the IoT Clinical Trials Europe conference on integrating IoT (the internet of things) and emerging technologies to optimise clinical trials and patient …

Developments in Digital Data

Developments in Digital Data 260 200 Exploristics

Developments in Digital Data

By Exploristics Chief Data Scientific Officer – Kimberley Hacquoil

When I first started working in the pharmaceutical industry, most clinical trials used paper case report forms (CRF) to collect information from patients. I remember the very …

Why Simulation is Needed to Optimise Both Adaptive & Fixed Clinical Trial Designs

Why Simulation is Needed to Optimise Both Adaptive & Fixed Clinical Trial Designs 260 200 Exploristics

Why Simulation is Needed to Optimise Both Adaptive & Fixed Clinical Trial Designs 

By Caroline O’Hare

Simulation is an invaluable tool for evaluating and mitigating the risks of clinical trials before conducting the studies in real time. Whilst helpful for …

Smarter Clinical Trial Design using Study Simulation Can Address Recruitment Challenges

Smarter Clinical Trial Design using Study Simulation Can Address Recruitment Challenges 260 200 Exploristics

By Aiden Flynn

Ten common questions:

1. What is clinical trial simulation?

In general terms, simulation uses a mathematical model to describe a system and process (i.e., a clinical study). It can be used to test and evaluate the process …

Drug Repurposing and Real-World Data: Lessons from COVID-19

Drug Repurposing and Real-World Data: Lessons from COVID-19 260 200 Exploristics

Statistical Insights: Drug Repurposing and RWD: Lessons from COVID: How the pandemic has heightened interest in unlocking the value of RWD.

Aiden Flynn, CEO, Exploristics

The world has changed as a result of COVID-19. This is particularly true for the …

Designing clinical studies for success and not failure

Designing clinical studies for success and not failure 260 200 Exploristics

Statistical Insights: Designing clinical studies for success and not failure.

Aiden Flynn, CEO, Exploristics

One of the most common complaints I have heard from biostatisticians is that they don’t get involved early enough in the clinical trial design process.  …

Going Synthetic with Real-World Data

Going Synthetic with Real-World Data 260 200 Exploristics

Aiden Flynn, CEO 01 December 2019

Real-world data has the potential to have a positive impact on the treatment of serious conditions, providing much-needed insights into the health and treatment of patients in an everyday setting. However, the collection of

The liberation of real-world data

The liberation of real-world data 260 200 Exploristics

Aiden Flynn, CEO 01 December 2019

The costs and complexities associated with drug development are fuelling the drive for more efficient healthcare delivery. Using real-world data resources leads to better informed projects, improved patient outcomes and a more effective evaluation